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Tuning responsiveness of polypeptide...

Johnson, Ashley J.

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Tuning responsiveness of polypeptide based block copolymers for drug delivery.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Tuning responsiveness of polypeptide based block copolymers for drug delivery./
Author:	Johnson, Ashley J.
Description:	187 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-06(E), Section: B.
Contained By:	Dissertation Abstracts International76-06B(E).
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3648324
ISBN:	9781321442533

Tuning responsiveness of polypeptide based block copolymers for drug delivery.
Johnson, Ashley J.

Tuning responsiveness of polypeptide based block copolymers for drug delivery. - 187 p.

Source: Dissertation Abstracts International, Volume: 76-06(E), Section: B.

Thesis (Ph.D.)--The University of Southern Mississippi, 2014.

This item must not be sold to any third party vendors.

The goal of this dissertation was to tune the pH response and self-assembled morphologies of amphiphilic polypeptide block copolymers for use as drug delivery vehicles. Poly(L-lysine) and poly(L-glutamtic acid) are responsive, ionizable polypeptides that undergo secondary structure transitions, from alpha-helix to random coil, whereby the change in conformation of the peptide chain results in changes to the global morphology of a self-assembled system. The main focus of this work was to understand how changes in the polymer composition and the local environment can lead to control over the behavior of the overall system. First, the responsive behavior of poly(L-lysine) block copolymers was studied in the presence of ionic liquids to determine how the assembly and response of the peptide was affected by the presence of an organic salt. Next, changes in the ring-opening polymerization of amino acid N-carboxyanhydride monomers were made to alter to the composition of homo-block polypeptides to statistical copolypeptides. An alpha-helix forming amino acid, leucine, was incorporated into the peptide chain to space charged lysine units from one another in order to alter the pH at which its secondary structure transition occurs. Leucine blocks were incorporated into linear block copolymers to afford more stability to the assembly as well as the capability of achieving novel morphologies. Finally, some of these materials have shown efficacy in controlled release of a loaded drug over an extended period of time at different pH and salt concentrations.

ISBN: 9781321442533Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Tuning responsiveness of polypeptide based block copolymers for drug delivery.
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020 $a 9781321442533
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100 1 $a Johnson, Ashley J. $3 3170853
245 1 0 $a Tuning responsiveness of polypeptide based block copolymers for drug delivery.
300 $a 187 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-06(E), Section: B.
500 $a Adviser: Daniel Savin.
502 $a Thesis (Ph.D.)--The University of Southern Mississippi, 2014.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a The goal of this dissertation was to tune the pH response and self-assembled morphologies of amphiphilic polypeptide block copolymers for use as drug delivery vehicles. Poly(L-lysine) and poly(L-glutamtic acid) are responsive, ionizable polypeptides that undergo secondary structure transitions, from alpha-helix to random coil, whereby the change in conformation of the peptide chain results in changes to the global morphology of a self-assembled system. The main focus of this work was to understand how changes in the polymer composition and the local environment can lead to control over the behavior of the overall system. First, the responsive behavior of poly(L-lysine) block copolymers was studied in the presence of ionic liquids to determine how the assembly and response of the peptide was affected by the presence of an organic salt. Next, changes in the ring-opening polymerization of amino acid N-carboxyanhydride monomers were made to alter to the composition of homo-block polypeptides to statistical copolypeptides. An alpha-helix forming amino acid, leucine, was incorporated into the peptide chain to space charged lysine units from one another in order to alter the pH at which its secondary structure transition occurs. Leucine blocks were incorporated into linear block copolymers to afford more stability to the assembly as well as the capability of achieving novel morphologies. Finally, some of these materials have shown efficacy in controlled release of a loaded drug over an extended period of time at different pH and salt concentrations.
590 $a School code: 0211.
650 4 $a Chemistry, Polymer. $3 1018428
690 $a 0495
710 2 $a The University of Southern Mississippi. $3 1018511
773 0 $t Dissertation Abstracts International $g 76-06B(E).
790 $a 0211
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3648324