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Factors associated with occurrence a...

Krishnan, Shilpa.

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Factors associated with occurrence and early detection of pressure ulcers following traumatic spinal cord injury.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Factors associated with occurrence and early detection of pressure ulcers following traumatic spinal cord injury./
Author:	Krishnan, Shilpa.
Description:	256 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.
Contained By:	Dissertation Abstracts International76-01B(E).
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3582565
ISBN:	9781321209013

Factors associated with occurrence and early detection of pressure ulcers following traumatic spinal cord injury.
Krishnan, Shilpa.

Factors associated with occurrence and early detection of pressure ulcers following traumatic spinal cord injury. - 256 p.

Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.

Thesis (Ph.D.)--University of Pittsburgh, 2014.

Pressure ulcers (PUs) are serious secondary complications occurring in individuals with spinal cord injury (SCI). PUs not only decrease quality of life, but can adversely affect physical, psychological, emotional and financial status. Although studies have investigated general risk factors for PUs, few have focused on the time period immediately following SCI when the inflammation associated with SCI may influence the body's ability to tolerate secondary tissue damage leading to occurrence of PUs. Biomarkers obtained from plasma and urine biofluids are commonly used to characterize inflammation.

ISBN: 9781321209013Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Factors associated with occurrence and early detection of pressure ulcers following traumatic spinal cord injury.
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020 $a 9781321209013
035 $a (MiAaPQ)AAI3582565
035 $a AAI3582565
040 $a MiAaPQ $c MiAaPQ
100 1 $a Krishnan, Shilpa. $3 2105936
245 1 0 $a Factors associated with occurrence and early detection of pressure ulcers following traumatic spinal cord injury.
300 $a 256 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.
500 $a Adviser: David Brienza.
502 $a Thesis (Ph.D.)--University of Pittsburgh, 2014.
520 $a Pressure ulcers (PUs) are serious secondary complications occurring in individuals with spinal cord injury (SCI). PUs not only decrease quality of life, but can adversely affect physical, psychological, emotional and financial status. Although studies have investigated general risk factors for PUs, few have focused on the time period immediately following SCI when the inflammation associated with SCI may influence the body's ability to tolerate secondary tissue damage leading to occurrence of PUs. Biomarkers obtained from plasma and urine biofluids are commonly used to characterize inflammation.
520 $a The Rehabilitation Engineering Research Center on SCI (RERC on SCI) recruited individuals with new traumatic SCI (TSCI). Data were collected at predetermined time points in acute care, inpatient rehabilitation and after discharge on the risk factors and incidence of PUs, and on plasma and urine inflammatory mediators. A secondary analysis was performed on data obtained from the 104 individuals with TSCI.
520 $a The purpose of this study was to investigate the association of clinical, demographic and inflammatory factors with the formation of PUs following TSCI during acute care hospitalization and inpatient rehabilitation. Severity of SCI (ASIA A) and presence of pneumonia were determined to predict PU incidence. Plasma concentrations of IL-1RA, GM-CSF, MIP-1alpha, IFN- gamma, IL-5, IL-17, MIG and MIP-1beta; and urine concentrations of IL-6, IL-8, IL-13, IP-10, MCP-1, IFN-gamma, IL-5, IL-17, MIG and TNF-alpha were associated with formation of PU, immediately after SCI. An increase in the plasma concentrations of IP-10 and a decrease in the urine concentrations of IFN-alpha were observed just before formation of the first PU. A significant association between presence of pneumonia and formation of PU was observed as compared to no pneumonia. This association between PU and pneumonia could be linked through inflammation. Increased plasma synthesis of IFN-alpha and urine synthesis of IL-1RA were associated with formation of PU in individuals with pneumonia.
520 $a The findings of this study suggest that an imbalance in the inflammatory response after SCI may be associated with formation of PUs. The findings also suggest an association between the presence of pneumonia and formation of PU, which could be linked through inflammation.
590 $a School code: 0178.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Education, Health. $3 1017668
690 $a 0317
690 $a 0982
690 $a 0573
690 $a 0680
710 2 $a University of Pittsburgh. $b Rehabilitation Science and Technology. $3 2105937
773 0 $t Dissertation Abstracts International $g 76-01B(E).
790 $a 0178
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3582565