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Reflectance and fluorescence spectro...

Finlay, Jarod C.

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Reflectance and fluorescence spectroscopies in photodynamic therapy.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Reflectance and fluorescence spectroscopies in photodynamic therapy./
Author:	Finlay, Jarod C.
Description:	343 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 6144.
Contained By:	Dissertation Abstracts International64-12B.
Subject:	Physics, Optics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3114925

Reflectance and fluorescence spectroscopies in photodynamic therapy.
Finlay, Jarod C.

Reflectance and fluorescence spectroscopies in photodynamic therapy. - 343 p.

Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 6144.

Thesis (Ph.D.)--The University of Rochester, 2004.

In vivo fluorescence spectroscopy during photodynamic therapy (PDT) has the potential to provide information on the distribution and degradation of sensitizers, the formation of fluorescent photoproducts and changes in tissue autofluorescence induced by photodynamic treatment. Reflectance spectroscopy allows quantification of light absorption and scattering in tissue. We present the results of several related studies of fluorescence and reflectance spectroscopy and their applications to photodynamic dosimetry.Subjects--Topical Terms:

1018756
Physics, Optics.

Reflectance and fluorescence spectroscopies in photodynamic therapy.
LDR:03475nmm 2200313 4500 001 1865694
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035 $a (UnM)AAI3114925
035 $a AAI3114925
040 $a UnM $c UnM
100 1 $a Finlay, Jarod C. $3 1953122
245 1 0 $a Reflectance and fluorescence spectroscopies in photodynamic therapy.
300 $a 343 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 6144.
500 $a Supervisor: Thomas H. Foster.
502 $a Thesis (Ph.D.)--The University of Rochester, 2004.
520 $a In vivo fluorescence spectroscopy during photodynamic therapy (PDT) has the potential to provide information on the distribution and degradation of sensitizers, the formation of fluorescent photoproducts and changes in tissue autofluorescence induced by photodynamic treatment. Reflectance spectroscopy allows quantification of light absorption and scattering in tissue. We present the results of several related studies of fluorescence and reflectance spectroscopy and their applications to photodynamic dosimetry.
520 $a First, we develop and test an empirical method for the correction of the distortions imposed on fluorescence spectra by absorption and scattering in turbid media. We characterize the irradiance dependence of the in vivo photobleaching of three sensitizers, protoporphyrin IX (PpIX), Photofrin and mTHPC, in a rat skin model. The photobleaching and photoproduct formation of PpIX exhibit irradiance dependence consistent with singlet oxygen (1O2)-mediated bleaching. The bleaching of mTHPC occurs in two phases, only one of which is consistent with a 1O 2-mediated mechanism. Photofrin's bleaching is independent of irradiance, although its photoproduct formation is not. This can be explained by a mixed-mechanism bleaching model.
520 $a Second, we develop an algorithm for the determination of tissue optical properties using diffuse reflectance spectra measured at a single source-detector separation and demonstrate the recovery of the hemoglobin oxygen dissociation curve from tissue-simulating phantoms containing human erythrocytes. This method is then used to investigate the heterogeneity of oxygenation response in murine tumors induced by carbogen inhalation. We find that while the response varies among animals and within each tumor, the majority of tumors exhibit an increase in blood oxygenation during carbogen breathing.
520 $a We present a forward-adjoint model of fluorescence propagation that uses the optical property information acquired from reflectance spectroscopy to obtain the undistorted fluorescence spectrum over a wide range of optical properties. Finally, we investigate the ability of the forward-adjoint theory to extract undistorted fluorescence and optical property information simultaneously from a single measured fluorescence spectrum. This method can recover the hemoglobin oxygen dissociation curve in tissue-simulating phantoms with an accuracy comparable to that of reflectance-based methods while correcting distortions in the fluorescence over a wide range of absorption and scattering coefficients.
590 $a School code: 0188.
650 4 $a Physics, Optics. $3 1018756
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Biophysics, Medical. $3 1017681
690 $a 0752
690 $a 0541
690 $a 0760
710 2 0 $a The University of Rochester. $3 1249304
773 0 $t Dissertation Abstracts International $g 64-12B.
790 1 0 $a Foster, Thomas H., $e advisor
790 $a 0188
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3114925