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Akt and ERK activation in human skel...

Mazzetti, Scott Anthony.

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Akt and ERK activation in human skeletal muscle: Dose-dependency of responses to increasing muscle contractions.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Akt and ERK activation in human skeletal muscle: Dose-dependency of responses to increasing muscle contractions./
Author:	Mazzetti, Scott Anthony.
Description:	80 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0611.
Contained By:	Dissertation Abstracts International64-02B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3080463

Akt and ERK activation in human skeletal muscle: Dose-dependency of responses to increasing muscle contractions.
Mazzetti, Scott Anthony.

Akt and ERK activation in human skeletal muscle: Dose-dependency of responses to increasing muscle contractions. - 80 p.

Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0611.

Thesis (Ph.D.)--Ball State University, 2003.

Akt activation mediates increases in glycogen synthesis in response to insulin in humans, while extracellular signal-regulated kinase (ERK) activation increases gene transcription and protein translation in response to endurance and resistance exercise. Akt activation increases only in response to intense muscle contractions and during hypertrophy in rats. No study has examined Akt and ERK activation with increasing numbers of intense muscle contractions in humans. Therefore, the primary objectives of this investigation were to determine if Akt activation increases in response to resistance exercise in humans, and to compare the changes in Akt and ERK activation in response to increasing numbers of muscle contractions.Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Akt and ERK activation in human skeletal muscle: Dose-dependency of responses to increasing muscle contractions.
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100 1 $a Mazzetti, Scott Anthony. $3 1943352
245 1 0 $a Akt and ERK activation in human skeletal muscle: Dose-dependency of responses to increasing muscle contractions.
300 $a 80 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0611.
500 $a Adviser: Scott W. Trappe.
502 $a Thesis (Ph.D.)--Ball State University, 2003.
520 $a Akt activation mediates increases in glycogen synthesis in response to insulin in humans, while extracellular signal-regulated kinase (ERK) activation increases gene transcription and protein translation in response to endurance and resistance exercise. Akt activation increases only in response to intense muscle contractions and during hypertrophy in rats. No study has examined Akt and ERK activation with increasing numbers of intense muscle contractions in humans. Therefore, the primary objectives of this investigation were to determine if Akt activation increases in response to resistance exercise in humans, and to compare the changes in Akt and ERK activation in response to increasing numbers of muscle contractions.
520 $a Akt and ERK activation were compared in muscle biopsy samples from 7 men before (Pre) and after (Post) knee extension and control protocols using enzyme linked-immunosorbent assays. Baseline information was obtained including body composition and maximal strength (1-RM). Subjects were familiarized with knee extensions performed at 70% of 1-RM and a specified repetition cadence (2sec up, 2sec down). Once/wk, subjects performed one protocol in random order: 1 repetition (rep), 10reps, 3 sets of 10reps (3 × 10), or 6min of sitting. Akt activation decreased 42%, while ERK activation increased 108% in response to 3 × 10 (p < 0.05). Akt and ERK activation did not change with 1 and 10reps, and thus their responses were not dose-dependent with resistance exercise in humans. The findings from this study represent the first indication that Akt activation is reduced in response to resistance exercise in human skeletal muscle, possibly to help mediate reductions in glycogen synthesis.
590 $a School code: 0013.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Health Sciences, Recreation. $3 1018003
650 4 $a Health Sciences, General. $3 1017817
690 $a 0433
690 $a 0307
690 $a 0575
690 $a 0566
710 2 0 $a Ball State University. $3 1018080
773 0 $t Dissertation Abstracts International $g 64-02B.
790 1 0 $a Trappe, Scott W., $e advisor
790 $a 0013
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3080463