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Vitamin A status and inflammation du...

Mentro, Anne M.

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Vitamin A status and inflammation during the first week of life in extremely premature infants at risk for bronchopulmonary dysplasia.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Vitamin A status and inflammation during the first week of life in extremely premature infants at risk for bronchopulmonary dysplasia./
Author:	Mentro, Anne M.
Description:	147 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-07, Section: B, page: 3390.
Contained By:	Dissertation Abstracts International65-07B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3141704
ISBN:	049688784X

Vitamin A status and inflammation during the first week of life in extremely premature infants at risk for bronchopulmonary dysplasia.
Mentro, Anne M.

Vitamin A status and inflammation during the first week of life in extremely premature infants at risk for bronchopulmonary dysplasia. - 147 p.

Source: Dissertation Abstracts International, Volume: 65-07, Section: B, page: 3390.

Thesis (Ph.D.)--The Ohio State University, 2004.

Bronchopulmonary dysplasia (BPD) is a chronic lung disease of prematurity affecting infants born at low gestational ages. The exact pathophysiology of BPD is unknown, but inflammation and oxidative stress immediately after birth are thought to be contributing factors. Vitamin A (retinol) is a potent antioxidant with anti-inflammatory properties. Although previous studies have revealed deficient plasma retinol concentrations and higher degrees of inflammation in premature infants, no studies have explored the collective relationship between these variables as they relate to oxygen dependence at 36 weeks postconceptional age. The purpose of this study was to explore relationships among plasma retinol, urinary interleukin-1 receptor antagonist (IL-1ra), and nutritional intake during the first days of life in premature infants high risk for BPD. Forty infants born at less than or equal to 30 weeks gestational age were recruited following birth. At day 1 and day 7 of life, 0.5 mL of whole blood, 1 mL of urine, and nutritional intake data were collected. Plasma retinol and IL-1ra concentrations were analyzed with HPLC and ELISA, respectively.

ISBN: 049688784XSubjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Vitamin A status and inflammation during the first week of life in extremely premature infants at risk for bronchopulmonary dysplasia.
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500 $a Adviser: Deborah K. Steward.
502 $a Thesis (Ph.D.)--The Ohio State University, 2004.
520 $a Bronchopulmonary dysplasia (BPD) is a chronic lung disease of prematurity affecting infants born at low gestational ages. The exact pathophysiology of BPD is unknown, but inflammation and oxidative stress immediately after birth are thought to be contributing factors. Vitamin A (retinol) is a potent antioxidant with anti-inflammatory properties. Although previous studies have revealed deficient plasma retinol concentrations and higher degrees of inflammation in premature infants, no studies have explored the collective relationship between these variables as they relate to oxygen dependence at 36 weeks postconceptional age. The purpose of this study was to explore relationships among plasma retinol, urinary interleukin-1 receptor antagonist (IL-1ra), and nutritional intake during the first days of life in premature infants high risk for BPD. Forty infants born at less than or equal to 30 weeks gestational age were recruited following birth. At day 1 and day 7 of life, 0.5 mL of whole blood, 1 mL of urine, and nutritional intake data were collected. Plasma retinol and IL-1ra concentrations were analyzed with HPLC and ELISA, respectively.
520 $a Plasma retinol concentrations remained stable over the first week despite increasing vitamin A intakes. Most infants had plasma values indicative of vitamin A deficiency. Plasma retinol values on day 1 and day 7 were positively related to IL-1ra concentrations on day 7 of life (p < 0.05 for both retinol values), suggesting that infants with greater inflammation had greater mobilization of retinol into the plasma. IL-1ra concentrations were very high throughout the first week and were indicative of substantial inflammation. For infants who required oxygen at 36 weeks, day 1 IL-1ra concentrations were significantly higher (p < 0.05) than those of infants without oxygen needs. Oxygen dependent infants also had lower mean vitamin A intakes (p = 0.05). These findings confirm that premature infants are vitamin A deficient and experience significant inflammation throughout the first week of life. Inflammatory markers produced within hours after birth may provide an early measure of BPD in extremely premature infants and increasing vitamin A intake may alleviate some of the early inflammation associated the disorder.
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