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Effects of muscimol injections on co...

Mojtahedian, Shahriar.

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Effects of muscimol injections on conditioned eyeblink versus limb flexion responses in the rabbit cerebellar interpositus nucleus.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Effects of muscimol injections on conditioned eyeblink versus limb flexion responses in the rabbit cerebellar interpositus nucleus./
Author:	Mojtahedian, Shahriar.
Description:	109 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-09, Section: B, page: 4441.
Contained By:	Dissertation Abstracts International65-09B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3145248
ISBN:	0496047876

Effects of muscimol injections on conditioned eyeblink versus limb flexion responses in the rabbit cerebellar interpositus nucleus.
Mojtahedian, Shahriar.

Effects of muscimol injections on conditioned eyeblink versus limb flexion responses in the rabbit cerebellar interpositus nucleus. - 109 p.

Source: Dissertation Abstracts International, Volume: 65-09, Section: B, page: 4441.

Thesis (Ph.D.)--University of Southern California, 2004.

Thompson and colleagues have demonstrated that the interpositus nucleus of the cerebellum is the essential locus for the classical conditioning of the somatic eyeblink response (e.g., McCormick et al., 1981; McCormick and Thompson, 1984). In preliminary findings, Donegan et al. (1983) reported that lesioning the cerebellar interpositus nucleus ipsilateral to the side of training also appears to abolish conditioned limb flexion responses. Previous studies (e.g., Chambers and Sprague, 1955) have suggested that the interpositus nucleus is somatotopically organized with the eye being represented laterally and the hindlimb medially. In the present study, we employed a double dissociation paradigm to examine the effects of muscimol (a GABAA agonist) injections on eyeblink versus limb flexion conditioned responses in the ipsilateral cerebellar interpositus nucleus of New Zealand white rabbits. For eyeblink conditioning, the conditioned stimulus (CS) was a 14-volt lamp bulb and the unconditioned stimulus (US) was a 3 psi corneal airpuff to the left eye. For limb flexion conditioning, the CS was a 1 KHz, 85--95 dB SPL tone and the US was a 3--5 mA shock to the upper left hindlimb. Upon training on both responses to a 60--100% criterion, the rabbits were then tested on eyeblink and limb flexion responses after injections of muscimol (0.1--0.3 mul of a 0.01--1.0 M solution) into either the lateral (eyeblink) or medial (limb flexion) interpositus nucleus. We have been able to successfully decrease or abolish the percent conditioned responses (CRs) of both the eyeblink and limb flexion conditioning selectively without affecting the other. These results thus lend further support for the notion of the existence of a somatotopic map (i.e., eyeblink versus limb flexion) in the interpositus nucleus for learning.

ISBN: 0496047876Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Effects of muscimol injections on conditioned eyeblink versus limb flexion responses in the rabbit cerebellar interpositus nucleus.
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245 1 0 $a Effects of muscimol injections on conditioned eyeblink versus limb flexion responses in the rabbit cerebellar interpositus nucleus.
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500 $a Source: Dissertation Abstracts International, Volume: 65-09, Section: B, page: 4441.
500 $a Adviser: Richard F. Thompson.
502 $a Thesis (Ph.D.)--University of Southern California, 2004.
520 $a Thompson and colleagues have demonstrated that the interpositus nucleus of the cerebellum is the essential locus for the classical conditioning of the somatic eyeblink response (e.g., McCormick et al., 1981; McCormick and Thompson, 1984). In preliminary findings, Donegan et al. (1983) reported that lesioning the cerebellar interpositus nucleus ipsilateral to the side of training also appears to abolish conditioned limb flexion responses. Previous studies (e.g., Chambers and Sprague, 1955) have suggested that the interpositus nucleus is somatotopically organized with the eye being represented laterally and the hindlimb medially. In the present study, we employed a double dissociation paradigm to examine the effects of muscimol (a GABAA agonist) injections on eyeblink versus limb flexion conditioned responses in the ipsilateral cerebellar interpositus nucleus of New Zealand white rabbits. For eyeblink conditioning, the conditioned stimulus (CS) was a 14-volt lamp bulb and the unconditioned stimulus (US) was a 3 psi corneal airpuff to the left eye. For limb flexion conditioning, the CS was a 1 KHz, 85--95 dB SPL tone and the US was a 3--5 mA shock to the upper left hindlimb. Upon training on both responses to a 60--100% criterion, the rabbits were then tested on eyeblink and limb flexion responses after injections of muscimol (0.1--0.3 mul of a 0.01--1.0 M solution) into either the lateral (eyeblink) or medial (limb flexion) interpositus nucleus. We have been able to successfully decrease or abolish the percent conditioned responses (CRs) of both the eyeblink and limb flexion conditioning selectively without affecting the other. These results thus lend further support for the notion of the existence of a somatotopic map (i.e., eyeblink versus limb flexion) in the interpositus nucleus for learning.
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