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Development and optimisation of poly...

Franklin, Jeffery D.

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Development and optimisation of polymeric matrices for use in biomolecular devices.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development and optimisation of polymeric matrices for use in biomolecular devices./
Author:	Franklin, Jeffery D.
Description:	155 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2210.
Contained By:	Dissertation Abstracts International64-05B.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ79456
ISBN:	0612794563

Development and optimisation of polymeric matrices for use in biomolecular devices.
Franklin, Jeffery D.

Development and optimisation of polymeric matrices for use in biomolecular devices. - 155 p.

Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2210.

Thesis (Ph.D.)--Carleton University (Canada), 2003.

Matrix development is the primary focus of this dissertation, with the intent of producing a functional polymeric matrix that displays both protein compatibility and good optical properties. The overall objectives include: (i) To prepare and optimise a PAm hydrogel formulation suitable for application in a bacteriorhodopsin based 3-D optical memory device. (ii) To design copolymers capable of post polymer grafting and photo-crosslinking that display improved long term stability and optical properties for application as a possible matrix material and (iii) To prepare novel hydroglass matrix materials displaying enhanced long term stability, optical clarity, and protein compatibility.

ISBN: 0612794563Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Development and optimisation of polymeric matrices for use in biomolecular devices.
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100 1 $a Franklin, Jeffery D. $3 1927700
245 1 0 $a Development and optimisation of polymeric matrices for use in biomolecular devices.
300 $a 155 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2210.
500 $a Adviser: Z. Y. Wang.
502 $a Thesis (Ph.D.)--Carleton University (Canada), 2003.
520 $a Matrix development is the primary focus of this dissertation, with the intent of producing a functional polymeric matrix that displays both protein compatibility and good optical properties. The overall objectives include: (i) To prepare and optimise a PAm hydrogel formulation suitable for application in a bacteriorhodopsin based 3-D optical memory device. (ii) To design copolymers capable of post polymer grafting and photo-crosslinking that display improved long term stability and optical properties for application as a possible matrix material and (iii) To prepare novel hydroglass matrix materials displaying enhanced long term stability, optical clarity, and protein compatibility.
520 $a The aqueous polymerisation of acrylamide and crosslinking with N, N-methylenebisacrylamide afforded hydrogels displaying high levels of light scattering. Optimisation of conditions such as the reduction of particulate matter within the cuvettes, utilisation of purified water, a 12% w/v Am concentration, a low concentration of MBA (<0.18% w/v), a low initiator concentration, a pH of approximately 6.0 and an incubation period of 3 weeks afforded PAm hydrogels with improved optical clarity (reduced light scattering). Further enhancement to the inherent light scattering properties within a PAm hydrogel was accomplished through the implementation of "refractive index matching". Water-soluble additives were utilised to better match the refractive index inhomogeneities throughout a given hydrogel and therefore lower the overall light scattering observed within the system.
520 $a Overall this dissertation reported: (i) The optical clarity of a PAm hydrogel can be improved through the optimisation of polymerisation conditions and can be further enhanced at significant levels via refractive index matching. The use of water-soluble additives for matching refractive index inhomogeneities within the hydrogel is a very simple and effective way to yield a matrix with a high degree of optical clarity. (ii) Photo-patternable acrylate copolymers, derived from HEA, may be prepared through the derivatization of pendant hydroxy-containing parent systems into cinnamate pendent polymers displaying changes in thermal, optical and physical properties and (iii) novel "hydroglass" matrices displaying enhanced long-term stability and optical clarity may be prepared from the aqueous free-radical polymerisation of several acrylate monomers and crosslinked with a rigid difunctional monomer such as piperazine diacrylamide. (Abstract shortened by UMI.)
590 $a School code: 0040.
650 4 $a Chemistry, Polymer. $3 1018428
690 $a 0495
710 2 0 $a Carleton University (Canada). $3 1018407
773 0 $t Dissertation Abstracts International $g 64-05B.
790 1 0 $a Wang, Z. Y., $e advisor
790 $a 0040
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ79456