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Investigation of the influence of th...

Sankovic, John Michael.

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Investigation of the influence of the local flow conditions inside a rotary blood pump on erythrocyte damage.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Investigation of the influence of the local flow conditions inside a rotary blood pump on erythrocyte damage./
Author:	Sankovic, John Michael.
Description:	199 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2697.
Contained By:	Dissertation Abstracts International67-05B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3218688
ISBN:	9780542703232

Investigation of the influence of the local flow conditions inside a rotary blood pump on erythrocyte damage.
Sankovic, John Michael.

Investigation of the influence of the local flow conditions inside a rotary blood pump on erythrocyte damage. - 199 p.

Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2697.

Thesis (Ph.D.)--Case Western Reserve University, 2006.

The predominant current uses of mechanical circulatory support devices are as a bridge to transplantation and to provide temporary pumping assistance after cardiac surgery in cases where the heart tissue needs to have the pumping work load removed to allow for healing. Several implantable, rotary ventricular assist devices have begun clinical trials as bridge to transplant devices with the eventual clinical goal of permanent implantation. This work seeks to quantify potential adverse effects of rotary blood pumps on erythrocytes. Rotary pumps inherently obtain their size advantages by utilizing a small blood chamber enclosing a high speed impeller, which leads to blood shear stresses that are generally higher than physiological. These increased stresses can severely impact erythrocytes, platelets, and leukocytes. In addition to high stress regions, blood pumps can have regions of flow stagnation and recirculation, increasing cell to surface contact and the activation of platelets, making them more prone to initiate thrombosis in the pump or at marginal downstream situations; sufficiently high stresses can cause blood cellular component destruction. Accurate measurements of the local stress conditions inside the pump, which are required to understand the effects of the blood pump flow field on the cellular components of blood, have been lacking. To address the need for those data, particle image velocimetry has been applied using an optically clear pump and a blood analog fluid to obtain planar measurements of mean velocity and velocity fluctuations, which allow determination of the local stresses. To assess blood damage, the index of hemolysis was determined for the pump operating with bovine blood. With knowledge of the flow conditions and global measurements of cellular damage, a damage model was developed to account for the stress history of the erythrocytes. The knowledge gained in this project will be directly applicable to the development of safer cardiac assist technology.

ISBN: 9780542703232Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Investigation of the influence of the local flow conditions inside a rotary blood pump on erythrocyte damage.
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100 1 $a Sankovic, John Michael. $3 1920354
245 1 0 $a Investigation of the influence of the local flow conditions inside a rotary blood pump on erythrocyte damage.
300 $a 199 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2697.
500 $a Adviser: Jaikrishnan R. Kadambi.
502 $a Thesis (Ph.D.)--Case Western Reserve University, 2006.
520 $a The predominant current uses of mechanical circulatory support devices are as a bridge to transplantation and to provide temporary pumping assistance after cardiac surgery in cases where the heart tissue needs to have the pumping work load removed to allow for healing. Several implantable, rotary ventricular assist devices have begun clinical trials as bridge to transplant devices with the eventual clinical goal of permanent implantation. This work seeks to quantify potential adverse effects of rotary blood pumps on erythrocytes. Rotary pumps inherently obtain their size advantages by utilizing a small blood chamber enclosing a high speed impeller, which leads to blood shear stresses that are generally higher than physiological. These increased stresses can severely impact erythrocytes, platelets, and leukocytes. In addition to high stress regions, blood pumps can have regions of flow stagnation and recirculation, increasing cell to surface contact and the activation of platelets, making them more prone to initiate thrombosis in the pump or at marginal downstream situations; sufficiently high stresses can cause blood cellular component destruction. Accurate measurements of the local stress conditions inside the pump, which are required to understand the effects of the blood pump flow field on the cellular components of blood, have been lacking. To address the need for those data, particle image velocimetry has been applied using an optically clear pump and a blood analog fluid to obtain planar measurements of mean velocity and velocity fluctuations, which allow determination of the local stresses. To assess blood damage, the index of hemolysis was determined for the pump operating with bovine blood. With knowledge of the flow conditions and global measurements of cellular damage, a damage model was developed to account for the stress history of the erythrocytes. The knowledge gained in this project will be directly applicable to the development of safer cardiac assist technology.
590 $a School code: 0042.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Mechanical. $3 783786
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
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710 2 0 $a Case Western Reserve University. $3 1017714
773 0 $t Dissertation Abstracts International $g 67-05B.
790 1 0 $a Kadambi, Jaikrishnan R., $e advisor
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791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3218688