東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back to Search results for [ null ]

Switch To: Labeled | MARC Mode | ISBD

Peptide fragmentation and amino acid...

Zhang, Qingfen.

Linked to FindBook

Google Book

Amazon

博客來

Peptide fragmentation and amino acid quantification by mass spectrometry.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Peptide fragmentation and amino acid quantification by mass spectrometry./
Author:	Zhang, Qingfen.
Description:	249 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0863.
Contained By:	Dissertation Abstracts International67-02B.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3207651
ISBN:	9780542550089

Peptide fragmentation and amino acid quantification by mass spectrometry.
Zhang, Qingfen.

Peptide fragmentation and amino acid quantification by mass spectrometry. - 249 p.

Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0863.

Thesis (Ph.D.)--The University of Arizona, 2006.

Research presented in this dissertation falls into two parts: fragmentation mechanisms of peptide and fragmentation mechanism of amino acid derivatives. The study of peptide fragmentation may help to improve protein identification by incorporating the rules governing this process into search algorithms. This study elucidates the chemical 'rules' governing peptide dissociation. It is believed that these 'rules' can be incorporated into searching algorithms to achieve better protein identification. The present study focuses on the effects of different amino acids on fragmentation. Amino acids with a wide range of different chemical and physical properties are investigated, including amino acids with hydrophilic side chains, amino acids with aliphatic side chains and alpha, beta, and gamma-amino acids without side chains. It can be concluded from the present studies that the different amino acid properties have great influence on the peptide fragmentation and spectrum appearance.

ISBN: 9780542550089Subjects--Topical Terms:

586156
Chemistry, Analytical.

Peptide fragmentation and amino acid quantification by mass spectrometry.
LDR:02481nmm 2200301 4500 001 1831470
005 20070511144444.5
008 130610s2006 eng d
020 $a 9780542550089
035 $a (UnM)AAI3207651
035 $a AAI3207651
040 $a UnM $c UnM
100 1 $a Zhang, Qingfen. $3 1920256
245 1 0 $a Peptide fragmentation and amino acid quantification by mass spectrometry.
300 $a 249 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0863.
500 $a Adviser: Vicki H. Wysocki.
502 $a Thesis (Ph.D.)--The University of Arizona, 2006.
520 $a Research presented in this dissertation falls into two parts: fragmentation mechanisms of peptide and fragmentation mechanism of amino acid derivatives. The study of peptide fragmentation may help to improve protein identification by incorporating the rules governing this process into search algorithms. This study elucidates the chemical 'rules' governing peptide dissociation. It is believed that these 'rules' can be incorporated into searching algorithms to achieve better protein identification. The present study focuses on the effects of different amino acids on fragmentation. Amino acids with a wide range of different chemical and physical properties are investigated, including amino acids with hydrophilic side chains, amino acids with aliphatic side chains and alpha, beta, and gamma-amino acids without side chains. It can be concluded from the present studies that the different amino acid properties have great influence on the peptide fragmentation and spectrum appearance.
520 $a The study of fragmentation mechanisms of amino acid derivatives is another focus of this dissertation. Based on the fragmentation mechanism study, a quantification method was developed. The method can distinguish glutamine with 15N-label at N-terminal amine vs. the side chain even if they have same molecular weight. Ammonia metabolism was successfully monitored by feeding mosquitoes with isotope-labeled compounds and subsequently measuring the amount of the labeled amino acids. This method demonstrates the power of mass spectrometry in metabolism studies.
590 $a School code: 0009.
650 4 $a Chemistry, Analytical. $3 586156
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Chemistry, Organic. $3 516206
690 $a 0486
690 $a 0487
690 $a 0490
710 2 0 $a The University of Arizona. $3 1017508
773 0 $t Dissertation Abstracts International $g 67-02B.
790 1 0 $a Wysocki, Vicki H., $e advisor
790 $a 0009
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3207651