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Effect of age on the functional conn...

Calhoun Haney, Rose.

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Effect of age on the functional connectivity of brain regions involved in olfaction.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Effect of age on the functional connectivity of brain regions involved in olfaction./
Author:	Calhoun Haney, Rose.
Description:	119 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2868.
Contained By:	Dissertation Abstracts International66-05B.
Subject:	Psychology, Physiological. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3175295
ISBN:	9780542136672

Effect of age on the functional connectivity of brain regions involved in olfaction.
Calhoun Haney, Rose.

Effect of age on the functional connectivity of brain regions involved in olfaction. - 119 p.

Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2868.

Thesis (Ph.D.)--University of California, San Diego and San Diego State University, 2005.

The present study investigated the functional interactions among brains regions typically involved in olfactory processing with the application of structural equation modeling (SEM) to functional magnetic resonance (fMRI) imaging data. fMRI data was obtained during an odor detection task from ten healthy young and ten healthy elderly gender matched participants. Interregional correlations from fMRI signal data were used to calculate path coefficients and were then compared between groups using a stacked model approach. Results demonstrated that the left hemisphere functional networks differed between age groups. Comparison of path coefficients showed stronger interactions in the young occurring between piriform-amydala, piriform-entorhinal, and amydala-hippocampal connections. Interestingly, a stronger functional interaction between the piriform-orbital frontal connection was observed in the elderly network. In contrast to the left hemisphere, right hemisphere networks did not differ between age groups. These findings revealed age-related changes in functional connectivity among brain regions involved in odor detection, as well as contributed to a growing body of literature suggesting possible compensatory mechanisms occurring in the aging brain.

ISBN: 9780542136672Subjects--Topical Terms:

1017869
Psychology, Physiological.

Effect of age on the functional connectivity of brain regions involved in olfaction.
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100 1 $a Calhoun Haney, Rose. $3 1913153
245 1 0 $a Effect of age on the functional connectivity of brain regions involved in olfaction.
300 $a 119 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2868.
500 $a Chair: Claire Murphy.
502 $a Thesis (Ph.D.)--University of California, San Diego and San Diego State University, 2005.
520 $a The present study investigated the functional interactions among brains regions typically involved in olfactory processing with the application of structural equation modeling (SEM) to functional magnetic resonance (fMRI) imaging data. fMRI data was obtained during an odor detection task from ten healthy young and ten healthy elderly gender matched participants. Interregional correlations from fMRI signal data were used to calculate path coefficients and were then compared between groups using a stacked model approach. Results demonstrated that the left hemisphere functional networks differed between age groups. Comparison of path coefficients showed stronger interactions in the young occurring between piriform-amydala, piriform-entorhinal, and amydala-hippocampal connections. Interestingly, a stronger functional interaction between the piriform-orbital frontal connection was observed in the elderly network. In contrast to the left hemisphere, right hemisphere networks did not differ between age groups. These findings revealed age-related changes in functional connectivity among brain regions involved in odor detection, as well as contributed to a growing body of literature suggesting possible compensatory mechanisms occurring in the aging brain.
520 $a The present study also applied SEM to fMRI data and compared functional networks between ten young and ten elderly gender matched participants during an olfactory recognition memory task. Age-related differences were observed in the left hemisphere functional network with stronger interactions occurring between the amygdala-hippocampal and amygdala-parahippocampal connections. Functional networks in the right hemisphere differed between age groups, with stronger interactions for the young occurring between the piriform-amygdala, piriform-entorhinal, and hippocampal-parahippocampal connections. Additionally, the elderly functional networks for both left and right hemispheres had a reduced number of significant functional pathways associated with the olfactory recognition memory task. This reduction in number of significant functional pathways corresponded with a significantly poorer performance by elderly on recognition accuracy. These findings suggest age-related changes in functional connectivity among brain regions involved in olfactory recognition memory, and support prior olfactory recognition memory research that suggests that the interaction between left and right hemispheres allows for optimal performance for more complex olfactory processing.
590 $a School code: 0385.
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791 $a Ph.D.
792 $a 2005
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