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Relating secondary structure to the ...

Hagan, Sharon Anne.

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Relating secondary structure to the mechanical properties of polypeptide hydrogels.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Relating secondary structure to the mechanical properties of polypeptide hydrogels./
Author:	Hagan, Sharon Anne.
Description:	198 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1978.
Contained By:	Dissertation Abstracts International65-04B.
Subject:	Engineering, Chemical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3132167
ISBN:	9780496794072

Relating secondary structure to the mechanical properties of polypeptide hydrogels.
Hagan, Sharon Anne.

Relating secondary structure to the mechanical properties of polypeptide hydrogels. - 198 p.

Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1978.

Thesis (Ph.D.)--Kansas State University, 2004.

Biomimetic hydrogels are being developed for use in medicine as drug delivery devices and tissue engineering matrices, and the mechanical properties of the materials play an important role in their performance. For example, in tissue engineering, gene expression and cell adhesion have been closely linked to the mechanical properties of the surrounding hydrogel matrix. In poly-L-lysine hydrogels, a five-fold increase in storage modulus, a 50% increase in equilibrium modulus, and a 62% decrease in swelling degree are shown to occur as the hydrogel network chains transition from an alpha-helix to a beta-sheet conformation. The manipulation of the network's mechanical behavior through changes in the secondary structure of the polymer chains offers an additional design variable in the development of biosynthetic materials.

ISBN: 9780496794072Subjects--Topical Terms:

1018531
Engineering, Chemical.

Relating secondary structure to the mechanical properties of polypeptide hydrogels.
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100 1 $a Hagan, Sharon Anne. $3 1910169
245 1 0 $a Relating secondary structure to the mechanical properties of polypeptide hydrogels.
300 $a 198 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1978.
500 $a Major Professor: Stevin H. Gehrke.
502 $a Thesis (Ph.D.)--Kansas State University, 2004.
520 $a Biomimetic hydrogels are being developed for use in medicine as drug delivery devices and tissue engineering matrices, and the mechanical properties of the materials play an important role in their performance. For example, in tissue engineering, gene expression and cell adhesion have been closely linked to the mechanical properties of the surrounding hydrogel matrix. In poly-L-lysine hydrogels, a five-fold increase in storage modulus, a 50% increase in equilibrium modulus, and a 62% decrease in swelling degree are shown to occur as the hydrogel network chains transition from an alpha-helix to a beta-sheet conformation. The manipulation of the network's mechanical behavior through changes in the secondary structure of the polymer chains offers an additional design variable in the development of biosynthetic materials.
520 $a Analogous to poly-L-lysine, elastin-mimetic proteins based on the consensus repeat sequence of elastin (VPGVG) undergo a temperature-dependent secondary structure transition from a random coil to a beta-spiral. In this research, chemically-crosslinked poly[(VPGVG)4(VPGKG)] hydrogels are shown to possess temperature- and pH-dependent swelling. Following scaling law predictions (G &sim; &phis;2n), the hydrogels have been shown to behave as ideal elastic networks when the crosslink density is varied at synthesis (theory: n = 9/4, experimental: n = 2.0 +/- 0.1), and behave as flexible networks above and below their structural transition temperature of 35°C (theory: n = 1/3, experimental: n = 0.45 +/- 0.06). Evaluation of published data on elastin-mimetic hydrogels shows that the hydrogels behave as ideal elastic networks for all crosslinking techniques, crosslink spacings, and crosslink functionalities reported.
520 $a As a contrast to chemically-crosslinked hydrogels, a novel elastin-mimetic triblock (EMT) copolymer was evaluated because of its potential use in cell encapsulation without potentially harmful side reactions. Unlike other thermally gelling copolymers, the EMT hydrogel shrinks to approximately 50% of its original size when heated from 30°C to 50°C in water. This physically-crosslinked hydrogel exhibits reproducible swelling kinetics (Dp &sim; 4 x 10-7 cm2/s), similar to chemically-crosslinked, thermally-responsive hydrogels such as poly(N-isopropylacrylamide). The addition of salts to the synthesis solution of EMT hydrogels reduces the equilibrium swelling by 85% and increases the shear modulus 14- to 17-fold depending on the type of salt.
590 $a School code: 0100.
650 4 $a Engineering, Chemical. $3 1018531
650 4 $a Engineering, Materials Science. $3 1017759
650 4 $a Chemistry, Polymer. $3 1018428
690 $a 0542
690 $a 0794
690 $a 0495
710 2 0 $a Kansas State University. $3 1017593
773 0 $t Dissertation Abstracts International $g 65-04B.
790 1 0 $a Gehrke, Stevin H., $e advisor
790 $a 0100
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3132167