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Early embryonic apoptosis in the pur...

Vega Thurber, Rebecca Lisette.

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Early embryonic apoptosis in the purple sea urchin, Strongylocentrotus purpuratus: Developmental timing, control, and responses to environmental disruption.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Early embryonic apoptosis in the purple sea urchin, Strongylocentrotus purpuratus: Developmental timing, control, and responses to environmental disruption./
Author:	Vega Thurber, Rebecca Lisette.
Description:	93 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 5774.
Contained By:	Dissertation Abstracts International66-11B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3197523
ISBN:	9780542432217

Early embryonic apoptosis in the purple sea urchin, Strongylocentrotus purpuratus: Developmental timing, control, and responses to environmental disruption.
Vega Thurber, Rebecca Lisette.

Early embryonic apoptosis in the purple sea urchin, Strongylocentrotus purpuratus: Developmental timing, control, and responses to environmental disruption. - 93 p.

Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 5774.

Thesis (Ph.D.)--Stanford University, 2006.

This dissertation characterizes a novel link between apoptosis and efflux transporters in early sea urchin development. Using a cell biological framework I have demonstrated that while embryos of the sea urchin Strongylocentrotus purpuratus are highly resistant to stress-induced apoptosis, disruption of the efflux transporter system circumvents or directly abolishes this resistance. In addition this dissertation has demonstrated that while apoptosis is stage dependent, occurs in low frequency, and is unnecessary for normal urchin development, it is advantageous during times of stress, providing urchin embryos a sensitive pathway to eliminate damaged cells in early development. This study also found that inducible apoptosis occurs in a temporally predictable fashion, peaking around the hatching stage. These findings confirm that chemo-sensitization via transporter inhibition has real embryological consequences. In addition, I have shown for the first time that small subtle variations in transporter substrate sensitivity significantly affect embryo toxin susceptibility, a result that has important implications for embryo health and survivorship.

ISBN: 9780542432217Subjects--Topical Terms:

1017686
Biology, Cell.

Early embryonic apoptosis in the purple sea urchin, Strongylocentrotus purpuratus: Developmental timing, control, and responses to environmental disruption.
LDR:02140nmm 2200289 4500 001 1820263
005 20061023071449.5
008 130610s2006 eng d
020 $a 9780542432217
035 $a (UnM)AAI3197523
035 $a AAI3197523
040 $a UnM $c UnM
100 1 $a Vega Thurber, Rebecca Lisette. $3 1909496
245 1 0 $a Early embryonic apoptosis in the purple sea urchin, Strongylocentrotus purpuratus: Developmental timing, control, and responses to environmental disruption.
300 $a 93 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 5774.
500 $a Adviser: David Epel.
502 $a Thesis (Ph.D.)--Stanford University, 2006.
520 $a This dissertation characterizes a novel link between apoptosis and efflux transporters in early sea urchin development. Using a cell biological framework I have demonstrated that while embryos of the sea urchin Strongylocentrotus purpuratus are highly resistant to stress-induced apoptosis, disruption of the efflux transporter system circumvents or directly abolishes this resistance. In addition this dissertation has demonstrated that while apoptosis is stage dependent, occurs in low frequency, and is unnecessary for normal urchin development, it is advantageous during times of stress, providing urchin embryos a sensitive pathway to eliminate damaged cells in early development. This study also found that inducible apoptosis occurs in a temporally predictable fashion, peaking around the hatching stage. These findings confirm that chemo-sensitization via transporter inhibition has real embryological consequences. In addition, I have shown for the first time that small subtle variations in transporter substrate sensitivity significantly affect embryo toxin susceptibility, a result that has important implications for embryo health and survivorship.
590 $a School code: 0212.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Zoology. $3 1018632
690 $a 0379
690 $a 0433
690 $a 0472
710 2 0 $a Stanford University. $3 754827
773 0 $t Dissertation Abstracts International $g 66-11B.
790 1 0 $a Epel, David, $e advisor
790 $a 0212
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3197523