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Leucine-enkephalin and sympathetic c...

Stanfill, Amber A.

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Leucine-enkephalin and sympathetic control of heart rate.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Leucine-enkephalin and sympathetic control of heart rate./
作者:	Stanfill, Amber A.
面頁冊數:	57 p.
附註:	Source: Masters Abstracts International, Volume: 40-06, page: 1455.
Contained By:	Masters Abstracts International40-06.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1408878
ISBN:	0493621482

Leucine-enkephalin and sympathetic control of heart rate.
Stanfill, Amber A.

Leucine-enkephalin and sympathetic control of heart rate. - 57 p.

Source: Masters Abstracts International, Volume: 40-06, page: 1455.

Thesis (M.S.)--University of North Texas Health Science Center at Fort Worth, 2001.

The following study examined the role of leucine-enkephalin in the sympathetic regulation of the cardiac pacemaker. Leucine-enkephalin (0.3 mM) was administered, by microdialysis into the interstitium of the sinoatrial node in 10 mongrel dogs in conjunction with either sympathetic nerve stimulation or infused norepinephrine. In study one, the right cardiac sympathetic nerves were isolated as they exit the stellate ganglion and stimulated to produce graded (low, 20--30; high 40--50 bpm) increases in heart rate. Once stimulation frequencies were determined, leucine-enkephalin (0.3mM) was added to the dialysis inflow and perfused at 5:1/min thereafter. The sympathetic stimulations were repeated after 5 and 20 min exposure to leucine-enkephalin. Study two was conducted to determine if the sympatholytic effect was prejunctional and post junctional in character. Norepinephrine was added to the dialysis inflow into the SA node in a concentration (6--9 muM) sufficient to produce an intermediate increase in heart rate. The average increase in heart rate was 35.2 +/- 1.8 bpm. Leucine-enkephalin was then combined with norepinephrine and sympathetic and parasympathetic responses were recorded at 5-min intervals for 20 minutes. (Abstract shortened by UMI.)

ISBN: 0493621482Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Leucine-enkephalin and sympathetic control of heart rate.
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500 $a Source: Masters Abstracts International, Volume: 40-06, page: 1455.
500 $a Adviser: James L. Caffrey.
502 $a Thesis (M.S.)--University of North Texas Health Science Center at Fort Worth, 2001.
520 $a The following study examined the role of leucine-enkephalin in the sympathetic regulation of the cardiac pacemaker. Leucine-enkephalin (0.3 mM) was administered, by microdialysis into the interstitium of the sinoatrial node in 10 mongrel dogs in conjunction with either sympathetic nerve stimulation or infused norepinephrine. In study one, the right cardiac sympathetic nerves were isolated as they exit the stellate ganglion and stimulated to produce graded (low, 20--30; high 40--50 bpm) increases in heart rate. Once stimulation frequencies were determined, leucine-enkephalin (0.3mM) was added to the dialysis inflow and perfused at 5:1/min thereafter. The sympathetic stimulations were repeated after 5 and 20 min exposure to leucine-enkephalin. Study two was conducted to determine if the sympatholytic effect was prejunctional and post junctional in character. Norepinephrine was added to the dialysis inflow into the SA node in a concentration (6--9 muM) sufficient to produce an intermediate increase in heart rate. The average increase in heart rate was 35.2 +/- 1.8 bpm. Leucine-enkephalin was then combined with norepinephrine and sympathetic and parasympathetic responses were recorded at 5-min intervals for 20 minutes. (Abstract shortened by UMI.)
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650 4 $a Biology, Animal Physiology. $3 1017835
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791 $a M.S.
792 $a 2001
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