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The fetal D1-dopaminergic system of ...

Strother, Wendy Noelle.

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The fetal D1-dopaminergic system of the suprachiasmatic nucleus: Its role in maternal/fetal entrainment of the circadian timing system.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The fetal D1-dopaminergic system of the suprachiasmatic nucleus: Its role in maternal/fetal entrainment of the circadian timing system./
Author:	Strother, Wendy Noelle.
Description:	128 p.
Notes:	Source: Dissertation Abstracts International, Volume: 58-05, Section: B, page: 2299.
Contained By:	Dissertation Abstracts International58-05B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9732600
ISBN:	0591421097

The fetal D1-dopaminergic system of the suprachiasmatic nucleus: Its role in maternal/fetal entrainment of the circadian timing system.
Strother, Wendy Noelle.

The fetal D1-dopaminergic system of the suprachiasmatic nucleus: Its role in maternal/fetal entrainment of the circadian timing system. - 128 p.

Source: Dissertation Abstracts International, Volume: 58-05, Section: B, page: 2299.

Thesis (Ph.D.)--University of Cincinnati, 1997.

The goal of these studies was to determine the role of the D1-dopaminergic receptor system of the suprachiasmatic nucleus (SCN) in maternal/fetal entrainment. In the first part of the dissertation, the ontogenic anatomy of the D1 system was studied. A receptor-transmitter mismatch was found between the prenatal appearance of D1-dopamine receptors in the SCN and the postnatal innervation of the SCN by tyrosine hydroxylase-positive neurons, suggesting a paracrine action of dopamine in the fetal SCN. Using a transplantation paradigm, we asked whether a D1-dopamine receptor agonist, SKF 38393, could set the phase of the grafted circadian pacemaker. The results demonstrated that SKF 38393 unambiguously set the phase of restored locomotor rhythms in adult hamsters bearing fetal whole tissue grafts containing the SCN, supporting the hypothesis that activation of the fetal dopaminergic system in the SCN plays an important role in the mechanism of maternal/fetal entrainment. And finally, the long-term effects of perinatal cocaine exposure on the adult circadian timing system were tested. Cocaine-treated animals showed altered phase responsiveness to light pulses given at specific times during the circadian cycle compared with saline control animals. The ability of early cocaine exposure to produce long-lasting effects on the phase shifting capabilities of the adult clock could have significant clinical implications.

ISBN: 0591421097Subjects--Topical Terms:

1017680
Biology, Neuroscience.

The fetal D1-dopaminergic system of the suprachiasmatic nucleus: Its role in maternal/fetal entrainment of the circadian timing system.
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035 $a (UnM)AAI9732600
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040 $a UnM $c UnM
100 1 $a Strother, Wendy Noelle. $3 1907147
245 1 4 $a The fetal D1-dopaminergic system of the suprachiasmatic nucleus: Its role in maternal/fetal entrainment of the circadian timing system.
300 $a 128 p.
500 $a Source: Dissertation Abstracts International, Volume: 58-05, Section: B, page: 2299.
500 $a Chair: Michael N. Lehman.
502 $a Thesis (Ph.D.)--University of Cincinnati, 1997.
520 $a The goal of these studies was to determine the role of the D1-dopaminergic receptor system of the suprachiasmatic nucleus (SCN) in maternal/fetal entrainment. In the first part of the dissertation, the ontogenic anatomy of the D1 system was studied. A receptor-transmitter mismatch was found between the prenatal appearance of D1-dopamine receptors in the SCN and the postnatal innervation of the SCN by tyrosine hydroxylase-positive neurons, suggesting a paracrine action of dopamine in the fetal SCN. Using a transplantation paradigm, we asked whether a D1-dopamine receptor agonist, SKF 38393, could set the phase of the grafted circadian pacemaker. The results demonstrated that SKF 38393 unambiguously set the phase of restored locomotor rhythms in adult hamsters bearing fetal whole tissue grafts containing the SCN, supporting the hypothesis that activation of the fetal dopaminergic system in the SCN plays an important role in the mechanism of maternal/fetal entrainment. And finally, the long-term effects of perinatal cocaine exposure on the adult circadian timing system were tested. Cocaine-treated animals showed altered phase responsiveness to light pulses given at specific times during the circadian cycle compared with saline control animals. The ability of early cocaine exposure to produce long-lasting effects on the phase shifting capabilities of the adult clock could have significant clinical implications.
590 $a School code: 0045.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Obstetrics and Gynecology. $3 1020690
650 4 $a Biology, Molecular. $3 1017719
690 $a 0317
690 $a 0379
690 $a 0380
690 $a 0307
710 2 0 $a University of Cincinnati. $3 960309
773 0 $t Dissertation Abstracts International $g 58-05B.
790 1 0 $a Lehman, Michael N., $e advisor
790 $a 0045
791 $a Ph.D.
792 $a 1997
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9732600