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Feasibility of T2-weighted blood oxy...

Shea, Steven M.

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Feasibility of T2-weighted blood oxygen level dependent magnetic resonance imaging in the heart to detect myocardial perfusion reserve differences due to stenosis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Feasibility of T2-weighted blood oxygen level dependent magnetic resonance imaging in the heart to detect myocardial perfusion reserve differences due to stenosis./
Author:	Shea, Steven M.
Description:	126 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3263.
Contained By:	Dissertation Abstracts International66-06B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3177805
ISBN:	0542174049

Feasibility of T2-weighted blood oxygen level dependent magnetic resonance imaging in the heart to detect myocardial perfusion reserve differences due to stenosis.
Shea, Steven M.

Feasibility of T2-weighted blood oxygen level dependent magnetic resonance imaging in the heart to detect myocardial perfusion reserve differences due to stenosis. - 126 p.

Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3263.

Thesis (Ph.D.)--Northwestern University, 2005.

Treatment of cardiovascular disease would benefit from a non-invasive, diagnostic imaging technique that could identify diseased myocardial regions without the use of radiopharmaceuticals or an external contrast agent. Blood oxygen level dependent (BOLD) MRI may meet these criteria. Previous cardiac BOLD research using T2* sequences has been hampered by image artifacts, long acquisition times, and small BOLD signal changes. Alternatively, T2-weighted sequences are more resistant to such imaging problems. The goal was to develop a cardiac, T2-weighted BOLD sequence that generates artifact free images which clearly show myocardial perfusion changes caused by coronary artery stenoses.

ISBN: 0542174049Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Feasibility of T2-weighted blood oxygen level dependent magnetic resonance imaging in the heart to detect myocardial perfusion reserve differences due to stenosis.
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040 $a UnM $c UnM
100 1 $a Shea, Steven M. $3 1905916
245 1 0 $a Feasibility of T2-weighted blood oxygen level dependent magnetic resonance imaging in the heart to detect myocardial perfusion reserve differences due to stenosis.
300 $a 126 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3263.
500 $a Adviser: Debiao Li.
502 $a Thesis (Ph.D.)--Northwestern University, 2005.
520 $a Treatment of cardiovascular disease would benefit from a non-invasive, diagnostic imaging technique that could identify diseased myocardial regions without the use of radiopharmaceuticals or an external contrast agent. Blood oxygen level dependent (BOLD) MRI may meet these criteria. Previous cardiac BOLD research using T2* sequences has been hampered by image artifacts, long acquisition times, and small BOLD signal changes. Alternatively, T2-weighted sequences are more resistant to such imaging problems. The goal was to develop a cardiac, T2-weighted BOLD sequence that generates artifact free images which clearly show myocardial perfusion changes caused by coronary artery stenoses.
520 $a Experiments with a T2-prepared steady-state free precession (SSFP) sequence were carried out using both selective coronary vasodilation and coronary stenosis animal models at 1.5T. The sequence was able to detect perfusion differences in the myocardium during stress with both animal models. More importantly, T2-related signal changes were shown to be correlated to flow changes, suggesting that regions affected by varying stenosis size could be differentiated.
520 $a The feasibility of 3T BOLD imaging was also investigated in an attempt to increase BOLD sensitivity. Achieving satisfactory image quality was a problem at 3T, meaning that a T2-prepared Fast Low Angle SHot (FLASH) technique was chosen for imaging because of its resistance to off-resonance, flow, and motion artifacts. Signal changes with T2-prepared FLASH at 3T were bigger than changes seen in previous T2-prepard FLASH experiments at 1.5T, suggesting that cardiac BOLD T2 changes were higher at 3T.
520 $a To further investigate BOLD T2 effects at 3T and 1.5T, T2-prepared SSFP and turbo spin-echo (TSE) sequences were imaged at both field strengths using an ischemia model in calf muscle generated by inflating a pressure cuff on the thigh. BOLD signal changes were found to be larger at 3T than 1.5T and T2-prepared SSFP performed as well as or better than TSE. Furthermore, we determined that this leg cuff model is an excellent method for testing BOLD sensitivity in sequences.
520 $a In conclusion, T2-weighted BOLD imaging was able to detect myocardial perfusion deficits in animal models and has the potential to be a sensitive marker of myocardial perfusion reserve.
590 $a School code: 0163.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
690 $a 0541
690 $a 0564
710 2 0 $a Northwestern University. $3 1018161
773 0 $t Dissertation Abstracts International $g 66-06B.
790 1 0 $a Li, Debiao, $e advisor
790 $a 0163
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3177805