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Biodegradable unsaturated poly(ester...

Guo, Kai.

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Biodegradable unsaturated poly(ester-amide)s and their hydrogels: Synthesis, characterization, biodegradation and biomedical applications as drug carriers.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Biodegradable unsaturated poly(ester-amide)s and their hydrogels: Synthesis, characterization, biodegradation and biomedical applications as drug carriers./
Author:	Guo, Kai.
Description:	157 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2093.
Contained By:	Dissertation Abstracts International66-04B.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3173353
ISBN:	0542108054

Biodegradable unsaturated poly(ester-amide)s and their hydrogels: Synthesis, characterization, biodegradation and biomedical applications as drug carriers.
Guo, Kai.

Biodegradable unsaturated poly(ester-amide)s and their hydrogels: Synthesis, characterization, biodegradation and biomedical applications as drug carriers. - 157 p.

Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2093.

Thesis (Ph.D.)--Cornell University, 2005.

We first synthesized a group of novel biodegradable unsaturated poly(ester-amide)s (UPEAs) by solution polycondensation of two unsaturated monomers, di- p-nitrophenyl fumarate and L-phenylalanine 2-butene-1,4-diol diester p-toluene sulfonate, and four other saturated monomers of different combinations. The Tg's of UPEAs are higher than those of the saturated PEAS (SPEAs) having similar chemical structure, and affected more by the >C=C< double bonds located in diamide part than by those in diester part of the UPEAs.

ISBN: 0542108054Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Biodegradable unsaturated poly(ester-amide)s and their hydrogels: Synthesis, characterization, biodegradation and biomedical applications as drug carriers.
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100 1 $a Guo, Kai. $3 1065271
245 1 0 $a Biodegradable unsaturated poly(ester-amide)s and their hydrogels: Synthesis, characterization, biodegradation and biomedical applications as drug carriers.
300 $a 157 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2093.
500 $a Adviser: Chih-Chang Chu.
502 $a Thesis (Ph.D.)--Cornell University, 2005.
520 $a We first synthesized a group of novel biodegradable unsaturated poly(ester-amide)s (UPEAs) by solution polycondensation of two unsaturated monomers, di- p-nitrophenyl fumarate and L-phenylalanine 2-butene-1,4-diol diester p-toluene sulfonate, and four other saturated monomers of different combinations. The Tg's of UPEAs are higher than those of the saturated PEAS (SPEAs) having similar chemical structure, and affected more by the >C=C< double bonds located in diamide part than by those in diester part of the UPEAs.
520 $a With the availability of the inherent >C=C< double bonds in the UPEAs' backbone, a series of biodegradable UPEA/PEG-DA (UPEA-G) hydrogels was formulated from UPEA and poly(ethylene glycol) diacrylate (PEG-DA) by UV photocrosslinking. The incorporation of the hydrophobic UPEA into the hydrophilic PEG-DA hydrogels increased their hydrophobicity, crosslinking density and mechanical strength, but reduced equilibrium swelling ratio (Qeq). When different types of UPEA were coupled with PEG-DA at the same feed ratio (20 wt%), the resultant hydrogels had similar Qeq and porous three-dimensional interior morphology, but different gel fraction (Gf) and compressive modulus. These differences in hydrogel property were correlated to the chemical structure of the UPEA precursors, i.e., different location of >C=C< double bonds in individual UPEA segments resulted in their different reactivity toward PEG-DA to form hydrogels.
520 $a The six-day biodegradation kinetics of UPEAs and UPEAs in both PBS buffer and alpha-chymotrypsin solution had been observed and their biodegradabilities were evaluated by weight loss. The effect of >C=C< double bonds on the UPEAs' biodegradabilities were investigated and discussed. As for biodegradable UPEA-G hydrogels, their biodegradability had been studied in both pure PBS buffer and alpha-chymotrypsin solution for two months. It is found that the biodegradability of UPEA-G hydrogels can be controlled by the concentration of alpha-chymotrypsin in the biodegradation media, the type of UPEA precursor, and the precursors' feed ratio.
520 $a When one of these biodegradable hydrogels, FPBe-G, was used as the carrier for hydrophobic drugs, indomethacin (IDM) and paclitaxel, the drug release profiles could be controlled by the hydrogels precursor feed ratio, the biodegradation rate of hydrogels and the pore sizes of hydrogels. The sustained paclitaxel release without obvious initial burst effect over the two-month period was achieved.
590 $a School code: 0058.
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0495
690 $a 0541
710 2 0 $a Cornell University. $3 530586
773 0 $t Dissertation Abstracts International $g 66-04B.
790 1 0 $a Chu, Chih-Chang, $e advisor
790 $a 0058
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3173353