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Epidemiology of Beryllium sensitizat...

Mikulski, Marek Andrzej.

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Epidemiology of Beryllium sensitization and pneumoconiosis in the population of former nuclear weapons workers and current and former conventional munitions workers from the Iowa army ammunition plant (IAAAP) in Burlington, Iowa.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Epidemiology of Beryllium sensitization and pneumoconiosis in the population of former nuclear weapons workers and current and former conventional munitions workers from the Iowa army ammunition plant (IAAAP) in Burlington, Iowa./
Author:	Mikulski, Marek Andrzej.
Description:	94 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-10, Section: B, page: .
Contained By:	Dissertation Abstracts International72-10B.
Subject:	Health Sciences, Occupational Health and Safety. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3461199
ISBN:	9781124743134

Epidemiology of Beryllium sensitization and pneumoconiosis in the population of former nuclear weapons workers and current and former conventional munitions workers from the Iowa army ammunition plant (IAAAP) in Burlington, Iowa.
Mikulski, Marek Andrzej.

Epidemiology of Beryllium sensitization and pneumoconiosis in the population of former nuclear weapons workers and current and former conventional munitions workers from the Iowa army ammunition plant (IAAAP) in Burlington, Iowa. - 94 p.

Source: Dissertation Abstracts International, Volume: 72-10, Section: B, page: .

Thesis (Ph.D.)--The University of Iowa, 2011.

Background. Nuclear and conventional weapons industry workers are at risk for exposures to beryllium, asbestos, high explosives and barium, all of which are implicated in the pathogenesis of pneumoconiosis. Beryllium has also been shown to cause sensitization (BeS) carrying a risk of progression to Chronic Beryllium Lung Disease (CBD). Data are lacking on the epidemiology of beryllium related health effects in conventional munitions workers and limited studies have been published on the prevalence of BeS in workers with minimal exposure. Data on the prevalence of pneumoconiosis in nuclear weapons workers is also lacking. The main objectives of this study were to determine prevalence and risk factors for beryllium sensitization in former nuclear and conventional munitions workers and rates of and risk factors for pneumoconiosis in former nuclear weapons workers, both cohorts from the Iowa Army Ammunition Plant (IAAAP) in Burlington, IA.

ISBN: 9781124743134Subjects--Topical Terms:

1017799
Health Sciences, Occupational Health and Safety.

Epidemiology of Beryllium sensitization and pneumoconiosis in the population of former nuclear weapons workers and current and former conventional munitions workers from the Iowa army ammunition plant (IAAAP) in Burlington, Iowa.
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020 $a 9781124743134
035 $a (UMI)AAI3461199
035 $a AAI3461199
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100 1 $a Mikulski, Marek Andrzej. $3 1684997
245 1 0 $a Epidemiology of Beryllium sensitization and pneumoconiosis in the population of former nuclear weapons workers and current and former conventional munitions workers from the Iowa army ammunition plant (IAAAP) in Burlington, Iowa.
300 $a 94 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-10, Section: B, page: .
500 $a Adviser: Laurence J. Fuortes.
502 $a Thesis (Ph.D.)--The University of Iowa, 2011.
520 $a Background. Nuclear and conventional weapons industry workers are at risk for exposures to beryllium, asbestos, high explosives and barium, all of which are implicated in the pathogenesis of pneumoconiosis. Beryllium has also been shown to cause sensitization (BeS) carrying a risk of progression to Chronic Beryllium Lung Disease (CBD). Data are lacking on the epidemiology of beryllium related health effects in conventional munitions workers and limited studies have been published on the prevalence of BeS in workers with minimal exposure. Data on the prevalence of pneumoconiosis in nuclear weapons workers is also lacking. The main objectives of this study were to determine prevalence and risk factors for beryllium sensitization in former nuclear and conventional munitions workers and rates of and risk factors for pneumoconiosis in former nuclear weapons workers, both cohorts from the Iowa Army Ammunition Plant (IAAAP) in Burlington, IA.
520 $a Methods. Former nuclear weapons workers were offered chest x-ray (CXR) and blood screening for sensitization with beryllium lymphocyte proliferation test (BeLPT) as part of the Department of Energy (DoE) Former Worker Medical Screening Program. Conventional munitions workers were offered BeLPT and clinical follow-up if sensitized, as part of a Department of Defense (DOD) funded study. Chest x-rays were reviewed by three readers according to the International Labour Organization's Classification system for Radiographs for Pneumoconioses (ILO system). Exposures under study were characterized qualitatively by the industrial hygiene team and based on former worker interviews and historical industrial hygiene records.
520 $a Results. The prevalence of beryllium sensitization in nuclear and conventional munitions workers was found to be slightly higher than in other workforces and weapons worker populations at low risk for exposure. The prevalence of parenchymal disease was higher in these nuclear weapons workers than in other DoE studies, while the prevalence of coincident parenchymal and pleural and isolated pleural disease was lower than in other nuclear weapons populations. Workers who occasionally dressed the copperberyllium alloy tools were found to have an increased risk of beryllium sensitization, compared to those in administrative or other jobs with insignificant potential for exposure on site. Exposure to beryllium, asbestos, high explosives or barium was not associated with lung disease in this population.
520 $a Conclusions. The findings from this study have potential policy implications for DOE and DOD to extend or implement beryllium surveillance and lung disease screening for their workforces and better control use of the copper-beryllium alloy tools in their production processes.
590 $a School code: 0096.
650 4 $a Health Sciences, Occupational Health and Safety. $3 1017799
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Health Sciences, Epidemiology. $3 1019544
690 $a 0354
690 $a 0573
690 $a 0766
710 2 $a The University of Iowa. $b Occupational and Environmental Health. $3 1684998
773 0 $t Dissertation Abstracts International $g 72-10B.
790 1 0 $a Fuortes, Laurence J., $e advisor
790 1 0 $a Sanderson, Wayne T. $e committee member
790 1 0 $a Hartley, Patrick G. $e committee member
790 1 0 $a Wang, Kai $e committee member
790 1 0 $a Cook, Thomas M. $e committee member
790 $a 0096
791 $a Ph.D.
792 $a 2011
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3461199