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Proteases of infectious agents

Dunn, Ben M.

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Proteases of infectious agents

Record Type:	Electronic resources : Monograph/item
Title/Author:	Proteases of infectious agents/ edited by Ben M. Dunn.{me_controlnum}
other author:	Dunn, Ben M.
Published:	San Diego, Calif. :Academic, : c1999.,
Description:	1 online resource (xvii, 282 p., [15] p. of col. plates) :ill. (some col.)
[NT 15003449]:	J. Erickson and M. Eissenstat, HIV Protease as a Target for the Design of Antiviral Agents for AIDS. -- C. Steink�uhler, A. Urbani, and R. De Francesco, Proteases of the Hepatitis C Virus. -- S. Abdel-Meguid and X. Qiu, Human Herpesvirus Proteases. -- C. Abad-Zapatero, R. Goldman, and K. Stewart, The Secreted Proteinases from Candida: Challenges for Structure-Aided Drug Design. -- M.N.G. James and E. Bergman, Proteolytic Enzymes of the Viruses of the Family Picornaviridae. -- C. Berry, Proteases as Drug Targets in the Treatment of Malaria. -- J. Cazzulo, Chagas Disease. -- H. Kido, Y. Chen, M. Murakami, Y. Beppu, and T. Towatari, Cellular Proteinases and Viral Infection: Influenza Virus, Sendai Virus, and HIV-1. -- M. Lively, Bacterial Type 1 Signal Peptidases. -- J.A. Garcia, M.R. Fern�andez-Fern�andez, and J.J. L�opez-Moya, Proteinases Involved in Plant Virus Genome Expression. -- Subject Index.
Subject:	Proteolytic enzymes. -
Online resource:	http://www.sciencedirect.com/science/book/9780124205109
ISBN:	9780124205109

Proteases of infectious agents
Proteases of infectious agents[electronic resource] /edited by Ben M. Dunn.{me_controlnum} - San Diego, Calif. :Academic,c1999. - 1 online resource (xvii, 282 p., [15] p. of col. plates) :ill. (some col.)

J. Erickson and M. Eissenstat, HIV Protease as a Target for the Design of Antiviral Agents for AIDS. -- C. Steink�uhler, A. Urbani, and R. De Francesco, Proteases of the Hepatitis C Virus. -- S. Abdel-Meguid and X. Qiu, Human Herpesvirus Proteases. -- C. Abad-Zapatero, R. Goldman, and K. Stewart, The Secreted Proteinases from Candida: Challenges for Structure-Aided Drug Design. -- M.N.G. James and E. Bergman, Proteolytic Enzymes of the Viruses of the Family Picornaviridae. -- C. Berry, Proteases as Drug Targets in the Treatment of Malaria. -- J. Cazzulo, Chagas Disease. -- H. Kido, Y. Chen, M. Murakami, Y. Beppu, and T. Towatari, Cellular Proteinases and Viral Infection: Influenza Virus, Sendai Virus, and HIV-1. -- M. Lively, Bacterial Type 1 Signal Peptidases. -- J.A. Garcia, M.R. Fern�andez-Fern�andez, and J.J. L�opez-Moya, Proteinases Involved in Plant Virus Genome Expression. -- Subject Index.

Proteases are enzymes that essentially "eat" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search. Proteases of Infectious Agents collects reviews from leading experts describing the latest information on the properties of key enzymes from a variety of viruses, fungi, and parasites. Each chapter provides the critical facts needed to initiate a drug discovery effort in that particular area. Key Features * Includes information on the basic biology and function of proteases * Provides global survey of current research efforts in protease inhibitors * Illustrates how structure-based drug design targets effective and selective compounds * Highlights important diseases that provide economically important targets * Describes the role of proteases as important new targets for drug discovery.

ISBN: 9780124205109

Source: 79195:79195Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

666586
Proteolytic enzymes.
Index Terms--Genre/Form:

542853
Electronic books.

LC Class. No.: QP609.P78 / P746 1999eb

Dewey Class. No.: 572/.76

National Agricultural Library Call No.: RC112 / .P76 1999

National Library of Medicine Call No.: 1999 F-117

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300 $a 1 online resource (xvii, 282 p., [15] p. of col. plates) : $b ill. (some col.)
505 0 $a J. Erickson and M. Eissenstat, HIV Protease as a Target for the Design of Antiviral Agents for AIDS. -- C. Steink�uhler, A. Urbani, and R. De Francesco, Proteases of the Hepatitis C Virus. -- S. Abdel-Meguid and X. Qiu, Human Herpesvirus Proteases. -- C. Abad-Zapatero, R. Goldman, and K. Stewart, The Secreted Proteinases from Candida: Challenges for Structure-Aided Drug Design. -- M.N.G. James and E. Bergman, Proteolytic Enzymes of the Viruses of the Family Picornaviridae. -- C. Berry, Proteases as Drug Targets in the Treatment of Malaria. -- J. Cazzulo, Chagas Disease. -- H. Kido, Y. Chen, M. Murakami, Y. Beppu, and T. Towatari, Cellular Proteinases and Viral Infection: Influenza Virus, Sendai Virus, and HIV-1. -- M. Lively, Bacterial Type 1 Signal Peptidases. -- J.A. Garcia, M.R. Fern�andez-Fern�andez, and J.J. L�opez-Moya, Proteinases Involved in Plant Virus Genome Expression. -- Subject Index.
505 0 0 $t HIV protease as a target for the design of antiviral agents for AIDS / $r John W. Erickson, Michael A. Eissenstat -- $t Proteases of the Hepatitis C virus / $r Andrea Urbani, Raffaele De Francesco, Christian Steink�uhler -- $t Human herpesvirus proteases / $r Xiayang Qiu, Sherin S. Abdel-Meguid -- $t Secreted proteinases from Candida : challenges for structure-aided drug design / $r Kent Stewart, Robert C. Goldman, Cele Abad-Zapatero -- $t Proteolytic enzymes of the viruses of the family picornaviridae / $r Ernest M. Bergmann, Michael N.G. James -- $t Proteases as drug targets for the treatment of malaria / $r Colin Berry -- $t Chagas disease / $r Juan Jos�e Cazzulo -- $t Cellular proteinases and viral infection : Influenza virus, Sendai virus, and HIV-1 / $r Hiroshi Kido ... [et al.] -- $t Bacterial type I signal peptidases / $r Mark O. Lively -- $t Proteinases involved in plant virus genome expression / $r Juan Antonio Garc�ia, Mar�ia Rosario Fern�andez-Fern�andez, Juan Jos�e L�opez-Moya.
520 $a Proteases are enzymes that essentially "eat" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search. Proteases of Infectious Agents collects reviews from leading experts describing the latest information on the properties of key enzymes from a variety of viruses, fungi, and parasites. Each chapter provides the critical facts needed to initiate a drug discovery effort in that particular area. Key Features * Includes information on the basic biology and function of proteases * Provides global survey of current research efforts in protease inhibitors * Illustrates how structure-based drug design targets effective and selective compounds * Highlights important diseases that provide economically important targets * Describes the role of proteases as important new targets for drug discovery.
588 $a Description based on print version record.
650 0 $a Proteolytic enzymes. $3 666586
650 0 $a Protease inhibitors. $3 750939
650 0 $a Microbial enzymes. $3 673515
650 1 2 $a Protease Inhibitors $x chemical synthesis. $3 1614821
650 1 2 $a Protease Inhibitors $x therapeutic use. $3 915192
650 2 2 $a Communicable Diseases $x enzymology. $3 1614822
650 2 2 $a Communicable Diseases $x therapy. $3 701539
650 4 $a Communicable diseases. $3 669516
650 6 $a Enzymes prot�eolytiques. $3 1614823
650 6 $a Antiprot�eases. $3 1614824
650 6 $a Enzymes microbiennes. $3 1614825
655 4 $a Electronic books. $2 lcsh $3 542853
700 1 $a Dunn, Ben M. $3 1614820
776 0 8 $i Print version: $t Proteases of infectious agents. $d San Diego, Calif. : Academic, c1999 $z 0124205100 $z 9780124205109 $w (DLC) 98089642 $w (OCoLC)41072679
856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780124205109
938 $a Ingram Digital eBook Collection $b IDEB $n 102511